The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways

URN to cite this document:: urn:nbn:de:bvb:355-epub-343250
DOI to cite this document:: 10.5283/epub.34325

Schmelzer, K. R. ; Wheelock, A. M. ; Dettmer, Katja ; Morin, D. ; Hammock, B. D.

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Date of publication of this fulltext: 12 Aug 2016 11:50

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Abstract

Ambient air is polluted with a mixture of pulmonary toxicants. Previous studies indicate that prior exposure to atmospheric oxidant pollutants such as ozone may significantly alter the response to other pollutants, such as 1-nitronaphthalene (1-NN). 1-NN, a component of the particulate exhaust from diesel engines, has been found at low concentrations in ambient air. Using a metabolomic approach, ...