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Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype

Ehlers, A., Oker, E., Bentink, Stefan, Lenze, D., Stein, H. and Hummel, M. (2008) Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype. Leukemia 22 (4), pp. 835-841.

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Other URL: http://www.nature.com/leu/journal/v22/n4/full/leu200812a.html


Abstract

A unique feature of the tumor cells (Hodgkin/Reed-Sternberg (HRS)) of classical Hodgkin lymphoma (cHL) is the loss of their B-cell phenotype despite their B-cell origin. Several lines of evidence suggest that epigenomic events, especially promoter DNA methylation, are involved in this silencing of many B-cell-associated genes. Here, we show that DNA demethylation alone or in conjunction with ...

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Item type:Article
Date:7 February 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
18256685PubMed ID
10.1038/leu.2008.12DOI
Keywords:methylation, acetylation, classical Hodgkin lymphoma, epigenetic
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34326
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