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Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype

Ehlers, A. ; Oker, E. ; Bentink, Stefan ; Lenze, D. ; Stein, H. ; Hummel, M.



Abstract

A unique feature of the tumor cells (Hodgkin/Reed-Sternberg (HRS)) of classical Hodgkin lymphoma (cHL) is the loss of their B-cell phenotype despite their B-cell origin. Several lines of evidence suggest that epigenomic events, especially promoter DNA methylation, are involved in this silencing of many B-cell-associated genes. Here, we show that DNA demethylation alone or in conjunction with ...

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