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Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory

Dettmer, Katja, Hanna, D., Whetstone, P., Hansen, R. and Hammock, B. D. (2007) Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Analytical and Bioanalytical Chemistry 388 (8), pp. 1643-1651.

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Other URL: http://link.springer.com/article/10.1007%2Fs00216-007-1301-4


Abstract

Autism is a complex neurodevelopmental disorder with unknown etiology. One hypothesis regarding etiology in autism is the “opioid peptide excess” theory that postulates that excessive amounts of exogenous opioid-like peptides derived from dietary proteins are detectable in urine and that these compounds may be pathophysiologically important in autism. A selective LC–MS/MS method was developed to ...

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Item type:Article
Date:August 2007
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
17520243PubMed ID
10.1007/s00216-007-1301-4DOI
Keywords:AutismNeuropeptidesβ-CasomorphinGliadinomorphinOpioid peptide excess theoryOn-line SPE–HPLC–MS/MS
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34327
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