Nested effects models for high-dimensional phenotyping screens

URN to cite this document:: urn:nbn:de:bvb:355-epub-343280
DOI to cite this document:: 10.5283/epub.34328

Markowetz, F. ; Kostka, D. ; Troyanskaya, O. G. ; Spang, Rainer

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Date of publication of this fulltext: 12 Aug 2016 12:07

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Abstract

Motivation: In high-dimensional phenotyping screens, a large number of cellular features is observed after perturbing genes by knockouts or RNA interference. Comprehensive analysis of perturbation effects is one of the most powerful techniques for attributing functions to genes, but not much work has been done so far to adapt statistical and computational methodology to the specific needs of ...