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Transition event statistics in genetics and disordered kinetics. Theoretical approaches for extracting rate distributions from experimental data

Vlad, M. O. ; Oefner, Peter J. ; Ross, J.



Abstract

We study the analogies between the theory of rate processes in disordered systems and the overdispersed molecular clocks in evolutionary biology. A biological “molecular clock” expresses the statistics of the number of amino acid or nucleotide substitutions during evolution. Random variations of the evolution rates lead to statistical (overdispersed) molecular clocks which are described by random ...

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