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Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma

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Dierlamm, J. ; Murga Penas, E. M. ; Bentink, Stefan ; Wessendorf, S. ; Berger, H. ; Hummel, M. ; Klapper, W. ; Lenze, D. ; Rosenwald, A. ; Haralambieva, E. ; Ott, G. ; Cogliatti, S. B. ; Möller, Peter ; Schwaenen, C. ; Stein, H. ; Löffler, M. ; Spang, Rainer ; Trumper, L. ; Siebert, Reiner
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Date of publication of this fulltext: 17 Aug 2016 13:52


BACKGROUND: The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma. DESIGN AND METHODS: We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling. RESULTS: A gain of 18q21 including MALT1 ...


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