Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma

URN to cite this document:

urn:nbn:de:bvb:355-epub-343653 Copy

DOI to cite this document:

10.5283/epub.34365 Copy

Dierlamm, J. ; Murga Penas, E. M. ; Bentink, Stefan ; Wessendorf, S. ; Berger, H. ; Hummel, M. ; Klapper, W. ; Lenze, D. ; Rosenwald, A. ; Haralambieva, E. ; Ott, G. ; Cogliatti, S. B. ; Möller, Peter ; Schwaenen, C. ; Stein, H. ; Löffler, M. ; Spang, Rainer ; Trumper, L. ; Siebert, Reiner

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Date of publication of this fulltext: 17 Aug 2016 13:52

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Details

Item type:	Article
Open Access Type:	Gold (mit APC - nicht UR)
Journal or Publication Title:	Haematologica
Publisher:	Ferrata Storti Foundation
Volume:	93
Number of Issue or Book Chapter:	5
Page Range:	pp. 688-696
Date:	May 2008
Institutions:	Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Informatics and Data Science > Department Computational Life Science > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:	Value Type 18367485 PubMed ID 10.3324/haematol.12057 DOI
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	34365

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Abstract

BACKGROUND: The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma. DESIGN AND METHODS: We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling. RESULTS: A gain of 18q21 including MALT1 ...

Abstract

BACKGROUND:
The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.
DESIGN AND METHODS:
We analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling.
RESULTS:
A gain of 18q21 including MALT1 was detected in 44 cases (38%) and was accompanied by a gain of BCL2 in 43 cases. All cases with a 18q21/MALT1 gain showed BCL2 protein whereas 79% in the group without a 18q21/MALT1 gain did so (p<0.001). Cases with 18q21/MALT1 gain more frequently showed an activated B-cell-like (ABC) gene expression signature (65%) than a germinal center B-cell-like (GCB) one (23%) (p<0.001). Ninety-eight genes including MALT1, BCL2, and some selected nuclear factor-kappaB target genes were differentially expressed between the two genetic groups of diffuse large B-cell lymphoma. By global testing of each chromosome, we identified 33 genes, all located on chromosome 18q, which were differentially expressed between the two genetic groups independently of the ABC/GCB status. In multivariate analysis, the 18q21/MALT1 status represented an independent negative prognostic factor for overall survival (p=0.03).
CONCLUSIONS:
In diffuse large B-cell lymphoma, gain of 18q21 including MALT1 is significantly associated with differential expression of genes located on 18q, the ABC gene expression subtype, increased BCL2 gene and protein expression and might indicate an unfavorable prognosis.

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Metadata last modified: 29 Sep 2021 07:40

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