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Detecting hierarchical structure in molecular characteristics of disease using transitive approximations of directed graphs

Jacob, Juby ; Jentsch, M. ; Kostka, Dennis ; Bentink, Stefan ; Spang, Rainer


MOTIVATION: Molecular diagnostics aims at classifying diseases into clinically relevant sub-entities based on molecular characteristics. Typically, the entities are split into subgroups, which might contain several variants yielding a hierarchical model of the disease. Recent years have introduced a plethora of new molecular screening technologies to molecular diagnostics. As a result molecular ...


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