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Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes

Stahl, S. ; Reinders, Yvonne ; Asan, E. ; Mothes, W. ; Conzelmann, E. ; Sickmann, A. ; Felbor, U.



Abstract

Cathepsins B and L are lysosomal cysteine proteases which have been implicated in a variety of pathological processes such as cancer, tumor angiogenesis, and neurodegeneration. However, only a few protein substrates have thus far been described and the mechanisms by which cathepsins B and L regulate cell proliferation, invasion, and apoptosis are poorly understood. Combined deficiency of both ...

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