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Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells

Stefan, E. ; Wiesner, B. ; Baillie, G. S. ; Mollajew, R. ; Henn, V. ; Lorenz, D. ; Furkert, J. ; Santamaria, K. ; Nedvetsky, P. ; Hundsrucker, Christian ; Beyermann, M. ; Krause, E. ; Pohl, P. ; Gall, I. ; MacIntyre, A. N. ; Bachmann, S. ; Houslay, M. D. ; Rosenthal, W. ; Klussmann, E.



Abstract

The cAMP/protein kinase A (PKA)-dependent insertion of water channel aquaporin-2 (AQP2)-bearing vesicles into the plasma membrane in renal collecting duct principal cells (AQP2 shuttle) constitutes the molecular basis of arginine vasopressin (AVP)-regulated water reabsorption. cAMP/PKA signaling systems are compartmentalized by A kinase anchoring proteins (AKAP) that tether PKA to subcellular ...

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