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Hsp90 Inhibition Affects Cell Metabolism by Disrupting Mitochondrial Protein Insertion

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Mycielska, Maria ; Wachsmuth, Christian J. ; Dettmer, Katja ; Wagner, Christine ; Oefner, Peter J. ; Geissler, Edward K. ; Lang, Sven A.
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 05 Sep 2016 13:45


Hsp90 is a molecular chaperone interacting with hundreds client proteins. Little is known, however, about Hsp90 influence on cancer cell metabolism. Here we show that the inhibition of Hsp90 affects indirectly glycolysis by disrupting mitochondrial insertion of the elements of Translocase of the Outer Membrane (TOM) complex in tumor cells. Improper insertion of Tom40 decreases the abundance of ...


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