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Hsp90 Inhibition Affects Cell Metabolism by Disrupting Mitochondrial Protein Insertion

Mycielska, Maria, Wachsmuth, Christian J., Dettmer, Katja, Wagner, Christine, Oefner, Peter J., Geissler, Edward K. and Lang, Sven A. (2014) Hsp90 Inhibition Affects Cell Metabolism by Disrupting Mitochondrial Protein Insertion. HSOA Journal of Cell Biology and Cell Metabolism 1, 002.

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Date of publication of this fulltext: 05 Sep 2016 13:45

Abstract

Hsp90 is a molecular chaperone interacting with hundreds client proteins. Little is known, however, about Hsp90 influence on cancer cell metabolism. Here we show that the inhibition of Hsp90 affects indirectly glycolysis by disrupting mitochondrial insertion of the elements of Translocase of the Outer Membrane (TOM) complex in tumor cells. Improper insertion of Tom40 decreases the abundance of ...

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Item type:Article
Date:2014
Institutions:Medicine > Lehrstuhl für Chirurgie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Keywords:Cancer; Glycolysis; Mitochondrial activity; Tom40
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34528
Owner only: item control page

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