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Expression profiling of human idiopathic dilated cardiomyopathy

Grzeskowiak, R. ; Witt, Henning ; Drungowski, M. ; Thermann, R. ; Hennig, S. ; Perrot, A. ; Osterziel, K. ; Klingbiel, D. ; Scheid, Stefanie ; Spang, Rainer


Objective: To investigate the global changes accompanying human dilated cardiomyopathy (DCM) we performed a large-scale expression screen using myocardial biopsies from a group of DCM patients with moderate heart failure. By hierarchical clustering and functional annotation of the deregulated genes we examined extensive changes in the cellular and molecular processes associated to DCM. Methods: ...


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