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Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds

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Nothdurfter, Caroline ; Tanasic, S. ; Di Benedetto, Barbara ; Uhr, M. ; Wagner, Eva-Maria ; Gilling, K. ; Parsons, C. ; Rein, T. ; Holsboer, F. ; Rupprecht, Rainer ; Rammes, G.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 13 Oct 2016 09:31


Lipid rafts have been shown to play an important role for G-protein mediated signal transduction and the function of ligand-gated ion channels including their modulation by psychopharmacological compounds. In this study, we investigated the functional significance of the membrane distribution of NMDA and GABAA receptor subunits in relation to the accumulation of the tricyclic antidepressant ...


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