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Evaluation of dilution and normalization strategies to correct for urinary output in HPLC-HRTOFMS metabolomics

Vogl, Franziska C., Mehrl, S., Heizinger, L., Schlecht, I., Zacharias, Helena, Ellmann, L., Nürnberger, N., Gronwald, Wolfram, Leitzmann, M. F., Rossert, J., Eckardt, K. U., Dettmer, Katja and Oefner, Peter J. (2016) Evaluation of dilution and normalization strategies to correct for urinary output in HPLC-HRTOFMS metabolomics. Analytical and Bioanalytical Chemistry (Anal Bioanal Chem).

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Abstract

Reliable identification of features distinguishing biological groups of interest in urinary metabolite fingerprints requires the control of total metabolite abundance, which may vary significantly as the kidneys adjust the excretion of water and solutes to meet the homeostatic needs of the body. Failure to account for such variation may lead to misclassification and accumulation of missing data ...

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Item type:Article
Date:4 November 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
27815612PubMed ID
10.1007/s00216-016-9974-1DOI
Keywords:Creatinine; LC-MS; Metabolic fingerprinting; Normalization; Osmolality; Urine
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34816
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