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Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis

Feist, M. ; Kemper, J. ; Taruttis, Franziska ; Rehberg, Thorsten ; Engelmann, Julia C. ; Gronwald, Wolfram ; Hummel, Michael ; Spang, Rainer ; Kube, Dieter



Abstract

A network of autocrine and paracrine signals defines B cell homeostasis and is thought to be involved in transformation processes. Investigating interactions of these microenvironmental factors and their relation to proto-oncogenes as c-Myc (MYC) is fundamental to understand the biology of B cell lymphoma. Therefore, B cells with conditional MYC expression were stimulated with CD40L, insulin-like ...

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