Go to content
UR Home

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma

Limm, K., Dettmer, Katja , Reinders, Jörg , Oefner, Peter J. and Bosserhoff, A. K. (2016) Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma. PLoS ONE 11 (8), e0160348.

[img]
Preview
License: Creative Commons Attribution 4.0
PDF - Published Version
Download (588kB)
Date of publication of this fulltext: 25 Nov 2016 08:41

at PubMed

at publisher (via DOI)

Other URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160348


Abstract

Deficiency of methylthioadenosine phosphorylase (MTAP) supports melanoma development and progression through accumulation of its substrate 5’-methylthioadenosine (MTA), which leads amongst others to a constitutive inhibition of protein arginine methyltransferases (PRMTs) and activation of the transcription factor AP-1 via the receptor ADORA2B. Genetic association studies have also suggested that ...

plus


Export bibliographical data



Item type:Article
Date:1 August 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
27479139PubMed ID
10.1371/journal.pone.0160348DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34883
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons