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Langguth, Berthold ; Landgrebe, Michael ; Schlee, Winfried ; Schecklmann, Martin ; Vielsmeier, Veronika ; Steffens, Thomas ; Staudinger, Susanne ; Frick, Hannah ; Frick, Ulrich

Differnet patterns of hearing loss among tinnitus patients: a latent class analysis of a large sample

Langguth, Berthold , Landgrebe, Michael, Schlee, Winfried, Schecklmann, Martin, Vielsmeier, Veronika, Steffens, Thomas, Staudinger, Susanne, Frick, Hannah und Frick, Ulrich (2017) Differnet patterns of hearing loss among tinnitus patients: a latent class analysis of a large sample. Frontiers in Neurology 8 (46), S. 1-27.

Veröffentlichungsdatum dieses Volltextes: 28 Mrz 2017 15:04
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.35158


Zusammenfassung

Background: The heterogeneity of tinnitus is a major challenge for tinnitus research. Even if a complex interaction of many factors is involved in the etiology of tinnitus, hearing loss (HL) has been identified as the most relevant etiologic factor. Here, we used a data-driven approach to identify patterns of hearing function in a large sample of tinnitus patients presenting in a tinnitus clinic. ...

Background: The heterogeneity of tinnitus is a major challenge for tinnitus research. Even if a complex interaction of many factors is involved in the etiology of tinnitus, hearing loss (HL) has been identified as the most relevant etiologic factor. Here, we used a data-driven approach to identify patterns of hearing function in a large sample of tinnitus patients presenting in a tinnitus clinic. Methods: Data from 2,838 patients presenting at the Tinnitus Center of the University Regensburg between 2007 and 2014 have been analyzed. Standard audiometric data were frequency-wise categorized in four categories [a: normal hearing (0-20 dB HL); b: moderate HL (25-50 dB HL; representing outer hair cell loss); c: severe HL (> 50 dB HL; representing outer and inner hair cell loss); d: no data available] and entered in a latent class analysis, a statistical method to find subtypes of cases in multivariate categorical data. To validate the clinical relevance of the identified latent classes, they were compared with respect to clinical and demographic characteristics of their members. Results: The classification algorithm identified eight distinct latent classes with an excellent separation. Patient classes differed with respect to demographic (e.g., age, gender) and clinical characteristics (e.g., tinnitus location, tinnitus severity, gradual, or abrupt onset, etc.). Discussion: Our results demonstrate that data-driven categorization of hearing function seems to be a promising approach for profiling tinnitus patients, as it revealed distinct subtypes that reflect prototypic forms of HL and that differ in several relevant clinical characteristics.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftFrontiers in Neurology
Verlag:Frontiers
Ort der Veröffentlichung:LAUSANNE
Band:8
Nummer des Zeitschriftenheftes oder des Kapitels:46
Seitenbereich:S. 1-27
Datum20 Februar 2017
InstitutionenMedizin > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde
Medizin > Lehrstuhl für Psychiatrie und Psychotherapie
Identifikationsnummer
WertTyp
10.3389/fneur.2017.00046DOI
Stichwörter / KeywordsMECHANISMS; SEVERITY; chronic tinnitus; hearing loss; cluster analysis; latent classes; audiometry
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-351581
Dokumenten-ID35158

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