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Langguth, Berthold ; Landgrebe, Michael ; Schlee, Winfried ; Schecklmann, Martin ; Vielsmeier, Veronika ; Steffens, Thomas ; Staudinger, Susanne ; Frick, Hannah ; Frick, Ulrich

Differnet patterns of hearing loss among tinnitus patients: a latent class analysis of a large sample

Langguth, Berthold , Landgrebe, Michael, Schlee, Winfried, Schecklmann, Martin, Vielsmeier, Veronika, Steffens, Thomas, Staudinger, Susanne, Frick, Hannah and Frick, Ulrich (2017) Differnet patterns of hearing loss among tinnitus patients: a latent class analysis of a large sample. Frontiers in Neurology 8 (46), pp. 1-27.

Date of publication of this fulltext: 28 Mar 2017 15:04
Article
DOI to cite this document: 10.5283/epub.35158


Abstract

Background: The heterogeneity of tinnitus is a major challenge for tinnitus research. Even if a complex interaction of many factors is involved in the etiology of tinnitus, hearing loss (HL) has been identified as the most relevant etiologic factor. Here, we used a data-driven approach to identify patterns of hearing function in a large sample of tinnitus patients presenting in a tinnitus clinic. ...

Background: The heterogeneity of tinnitus is a major challenge for tinnitus research. Even if a complex interaction of many factors is involved in the etiology of tinnitus, hearing loss (HL) has been identified as the most relevant etiologic factor. Here, we used a data-driven approach to identify patterns of hearing function in a large sample of tinnitus patients presenting in a tinnitus clinic. Methods: Data from 2,838 patients presenting at the Tinnitus Center of the University Regensburg between 2007 and 2014 have been analyzed. Standard audiometric data were frequency-wise categorized in four categories [a: normal hearing (0-20 dB HL); b: moderate HL (25-50 dB HL; representing outer hair cell loss); c: severe HL (> 50 dB HL; representing outer and inner hair cell loss); d: no data available] and entered in a latent class analysis, a statistical method to find subtypes of cases in multivariate categorical data. To validate the clinical relevance of the identified latent classes, they were compared with respect to clinical and demographic characteristics of their members. Results: The classification algorithm identified eight distinct latent classes with an excellent separation. Patient classes differed with respect to demographic (e.g., age, gender) and clinical characteristics (e.g., tinnitus location, tinnitus severity, gradual, or abrupt onset, etc.). Discussion: Our results demonstrate that data-driven categorization of hearing function seems to be a promising approach for profiling tinnitus patients, as it revealed distinct subtypes that reflect prototypic forms of HL and that differ in several relevant clinical characteristics.



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Details

Item typeArticle
Journal or Publication TitleFrontiers in Neurology
Publisher:Frontiers
Place of Publication:LAUSANNE
Volume:8
Number of Issue or Book Chapter:46
Page Range:pp. 1-27
Date20 February 2017
InstitutionsMedicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde
Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number
ValueType
10.3389/fneur.2017.00046DOI
KeywordsMECHANISMS; SEVERITY; chronic tinnitus; hearing loss; cluster analysis; latent classes; audiometry
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-351581
Item ID35158

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