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Comprehensive metaboproteomics of Burkitt's and diffuse large B-cell lymphoma cell lines and primary tumor tissues reveals distinct differences in pyruvate content and metabolism

Schwarzfischer, Philipp ; Reinders, Jörg ; Dettmer, Katja ; Kleo, K. ; Dimitrova, L. ; Hummel, M. ; Feist, M. ; Kube, D. ; Szczepanowski, M. ; Klapper, W. ; Taruttis, Franziska ; Engelmann, Julia C. ; Spang, Rainer ; Gronwald, Wolfram ; Oefner, Peter J.



Abstract

Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) are pathologically and clinically distinct subtypes of aggressive non-Hodgkin B-cell lymphoma. To learn more about their biology, we employed metabolomic and proteomic methods to study both established cell lines as well as cryopreserved and formalin-fixed paraffin-embedded (FFPE) tissue sections of BL and DLBCL. Strikingly, NMR ...

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