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Comprehensive metaboproteomics of Burkitt's and diffuse large B-cell lymphoma cell lines and primary tumor tissues reveals distinct differences in pyruvate content and metabolism

Schwarzfischer, Philipp, Reinders, Jörg, Dettmer, Katja , Kleo, K., Dimitrova, L., Hummel, M., Feist, M., Kube, D., Szczepanowski, M., Klapper, W., Taruttis, Franziska, Engelmann, Julia C. , Spang, Rainer, Gronwald, Wolfram and Oefner, Peter J. (2017) Comprehensive metaboproteomics of Burkitt's and diffuse large B-cell lymphoma cell lines and primary tumor tissues reveals distinct differences in pyruvate content and metabolism. Journal of Proteome Research 16, pp. 1105-1120.

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Abstract

Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) are pathologically and clinically distinct subtypes of aggressive non-Hodgkin B-cell lymphoma. To learn more about their biology, we employed metabolomic and proteomic methods to study both established cell lines as well as cryopreserved and formalin-fixed paraffin-embedded (FFPE) tissue sections of BL and DLBCL. Strikingly, NMR ...

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Item type:Article
Date:6 February 2017
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
28161958PubMed ID
10.1021/acs.jproteome.6b00164DOI
Keywords:PROTEIN EXPRESSION PROFILES; NEXT-GENERATION; CANCER; SIGNATURES; QUANTIFICATION; CLASSIFICATION; METABOLOMICS; DIAGNOSIS; SUBTYPES; BIOLOGY; metabolomics; proteomics; FFPE; BL; DLBCL; NMR; SWATH-MS; pyruvate
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35172
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