Go to content
UR Home

Early dissemination seeds metastasis in breast cancer

Hosseini, H. ; Obradovic, M. M. ; Hoffmann, M. ; Harper, K. L. ; Sosa, M. S. ; Werner-Klein, M. ; Nanduri, L. K. ; Werno, C. ; Ehrl, C. ; Maneck, M. ; Patwary, N. ; Haunschild, G. ; Guzvic, M. ; Reimelt, C. ; Grauvogl, Michael ; Eichner, N. ; Weber, F. ; Hartkopf, A. D. ; Taran, F. A. ; Brucker, S. Y. ; Fehm, T. ; Rack, B. ; Buchholz, S. ; Spang, Rainer ; Meister, Gunter ; Aguirre-Ghiso, J. A. ; Klein, Christoph A.



Abstract

Accumulating data suggest that metastatic dissemination often occurs early during tumour formation, but the mechanisms of early metastatic spread have not yet been addressed. Here, by studying metastasis in a HER2-driven mouse breast cancer model, we show that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 4239

Dissertations: dissertationen@ur.de
0941 943 3904

Research data: daten@ur.de
0941 943 4239

Contact persons