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Early dissemination seeds metastasis in breast cancer

Hosseini, H. ; Obradovic, M. M. ; Hoffmann, M. ; Harper, K. L. ; Sosa, M. S. ; Werner-Klein, M. ; Nanduri, L. K. ; Werno, C. ; Ehrl, C. ; Maneck, M. ; Patwary, N. ; Haunschild, G. ; Guzvic, M. ; Reimelt, C. ; Grauvogl, Michael ; Eichner, N. ; Weber, F. ; Hartkopf, A. D. ; Taran, F. A. ; Brucker, S. Y. ; Fehm, T. ; Rack, B. ; Buchholz, S. ; Spang, Rainer ; Meister, Gunter ; Aguirre-Ghiso, J. A. ; Klein, Christoph A.


Accumulating data suggest that metastatic dissemination often occurs early during tumour formation, but the mechanisms of early metastatic spread have not yet been addressed. Here, by studying metastasis in a HER2-driven mouse breast cancer model, we show that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes ...


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