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Molecular Tools for the NPY Y₄ Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y₁R Antagonists

Kuhn, Kilian (2017) Molecular Tools for the NPY Y₄ Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y₁R Antagonists. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Oct 2017 07:03

Abstract (English)

The neuropeptide Y family comprises three 36-amino acid peptides, namely neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP). In humans, the three peptides activate four functionally expressed G-protein coupled receptors (Y1R, Y2R, Y4R and Y5R) and contribute to the regulation of numerous (patho)physiological processes such as feeding behavior, pain sensitivity or the formation ...

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Translation of the abstract (German)

Die Neuropeptid Y Familie umfasst vier G-Protein gekoppelte Rezeptoren (Y1R, Y2R, Y4R und Y5R), die durch drei endogene Liganden, Neuropeptid Y (NPY), Peptid YY (PYY) und das pankreatische Polypeptid (PP) aktiviert werden. Die NPY Familie ist an der Regulation einer Vielzahl von physiologischen und pathophysiologischen Prozessen beteiligt. Hierzu gehören die Nahrungsaufnahme, das ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2 October 2017
Referee:Prof. Dr. A. Buschauer
Date of exam:17 March 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Neuropeptide Y; pancreatic polypeptide; NPY Y4 receptor ligands; radioligand; carbamoylguanidine; aza-peptides; peptidic antagonists; cross-metathesis
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35445
Owner only: item control page

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