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Fluorescence- and radio-labeling of Lys4,Nle17,30hPP yields molecular tools for the NPY Y4 receptor

Dukorn, Stefanie, Littmann, Timo, Keller, Max, Kuhn, Kilian K., Cabrele, Chiara , Baumeister, Paul, Bernhardt, Günther and Buschauer, Armin (2017) Fluorescence- and radio-labeling of Lys4,Nle17,30hPP yields molecular tools for the NPY Y4 receptor. Bioconjugate Chemistry.

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Other URL: https://www.ncbi.nlm.nih.gov/pubmed/28345900


Abstract

The neuropeptide Y (NPY) Y-4 receptor (Y4R) is involved in energy homeostasis and considered a potential drug target for the treatment of obesity. Only a few molecular tools, i.e., radiolabeled and fluorescent ligands, for the investigation of the Y4R were reported. Previously, [Lys(4)]hPP proved to be an appropriate full-length PP analog to prepare a fluorescent ligand by derivatization at the ...

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Item type:Article
Date:27 March 2017
Additional Information (public):Supplementary material available online
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1021/acs.bioconjchem.7b00103DOI
28345900PubMed ID
Keywords:PANCREATIC-POLYPEPTIDE RECEPTORS; HIGH-AFFINITY RADIOLIGAND; NEUROPEPTIDE-Y; FUNCTIONAL EXPRESSION; AGONIST BINDING; HIGHLY POTENT; LIGANDS; ANALOGS; RAT; ANTAGONISTS;
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35478
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