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Fluorescence- and radio-labeling of Lys4,Nle17,30hPP yields molecular tools for the NPY Y4 receptor

Dukorn, Stefanie ; Littmann, Timo ; Keller, Max ; Kuhn, Kilian K. ; Cabrele, Chiara ; Baumeister, Paul ; Bernhardt, Günther ; Buschauer, Armin



Abstract

The neuropeptide Y (NPY) Y-4 receptor (Y4R) is involved in energy homeostasis and considered a potential drug target for the treatment of obesity. Only a few molecular tools, i.e., radiolabeled and fluorescent ligands, for the investigation of the Y4R were reported. Previously, [Lys(4)]hPP proved to be an appropriate full-length PP analog to prepare a fluorescent ligand by derivatization at the ...

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