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The Influence of Metformin and TGF-β2 on Proliferation and Migration of Glioblastoma Cells

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Meyer, Anne-Louise
Date of publication of this fulltext: 24 Apr 2017 07:18

Abstract (English)

To this day, glioblastoma (GBM) remains a brain tumor impossible to cure. Among its tumor properties are rapid proliferation and aggressive migration, two hallmarks investigated in this study. GBM's rapid recurrence after treatment is attributed to tumor cells exhibiting stem cell properties, the so called brain tumor initiating cells (BTICs). These are targeted by the anti-diabetic drug ...


Translation of the abstract (German)

Das Glioblastom (GBM) ist ein bis heute nicht heilbarer Hirntumor. Diese Studie untersuchte zwei der wichtigsten Tumoreigenschaften des Glioblastoms, seine rasche Proliferation und seine Migration. Die hohe Rezidivrate bei Glioblastompatienten wird einer Zellpopulation mit Stammzelleigenschaften zugeschrieben, den sogenannten Hirntumor-initiierenden Zellen (BTICs). Bisherige Studien zeigten, dass ...


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