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The Influence of Metformin and TGF-β2 on Proliferation and Migration of Glioblastoma Cells

Meyer, Anne-Louise (2017) The Influence of Metformin and TGF-β2 on Proliferation and Migration of Glioblastoma Cells. PhD, Universität Regensburg.

License: Creative Commons Attribution No Derivatives 4.0
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Date of publication of this fulltext: 24 Apr 2017 07:18

Abstract (English)

To this day, glioblastoma (GBM) remains a brain tumor impossible to cure. Among its tumor properties are rapid proliferation and aggressive migration, two hallmarks investigated in this study. GBM's rapid recurrence after treatment is attributed to tumor cells exhibiting stem cell properties, the so called brain tumor initiating cells (BTICs). These are targeted by the anti-diabetic drug ...


Translation of the abstract (German)

Das Glioblastom (GBM) ist ein bis heute nicht heilbarer Hirntumor. Diese Studie untersuchte zwei der wichtigsten Tumoreigenschaften des Glioblastoms, seine rasche Proliferation und seine Migration. Die hohe Rezidivrate bei Glioblastompatienten wird einer Zellpopulation mit Stammzelleigenschaften zugeschrieben, den sogenannten Hirntumor-initiierenden Zellen (BTICs). Bisherige Studien zeigten, dass ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:24 April 2017
Referee:Prof. Dr. Peter Hau
Date of exam:19 April 2017
Institutions:Medicine > Lehrstuhl für Neurologie
Keywords:Glioblastom; Metformin; TGF-beta2; Proliferation; Migration
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35561
Owner only: item control page


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