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Pharmacological tools for the NPY receptors: [³⁵S]GTPγS binding assays, luciferase gene reporter assays and labeled peptides

URN to cite this document:
urn:nbn:de:bvb:355-epub-356112
DOI to cite this document:
10.5283/epub.35611
Dukorn, Stefanie
Date of publication of this fulltext: 22 Jan 2018 06:27


Abstract (English)

The neuropeptide Y (NPY) family comprises the 36-amino acid peptides neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). In humans, the biological effects of these peptides are mediated by four functionally expressed receptor subtypes, designated Y1, Y2, Y4 and Y5 receptors (Y1R, Y2R, Y4R, Y5R). Among the NPY receptors the Y4R is unique, as it prefers PP over NPY and PYY as ...

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Translation of the abstract (German)

Zur Neuropeptid Y (NPY) Familie zählen die Peptide Neuropeptid Y (NPY), Peptid YY (PYY) und das Pankreatische Polypeptid (PP), die jeweils 36 Aminosäuren besitzen. Im Menschen werden die biologischen Effekte durch vier Rezeptorsubtypen (Y1R, Y2R, Y4R, Y5R) vermittelt. Unter den NPY Rezeptoren besitzt der Y4R eine besondere Stellung, weil nur PP mit hoher Affinität an diesen Rezeptor bindet und ...

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