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Pharmacological tools for the NPY receptors: [³⁵S]GTPγS binding assays, luciferase gene reporter assays and labeled peptides

Dukorn, Stefanie (2018) Pharmacological tools for the NPY receptors: [³⁵S]GTPγS binding assays, luciferase gene reporter assays and labeled peptides. PhD, Universität Regensburg.

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Date of publication of this fulltext: 22 Jan 2018 06:27

Abstract (English)

The neuropeptide Y (NPY) family comprises the 36-amino acid peptides neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP). In humans, the biological effects of these peptides are mediated by four functionally expressed receptor subtypes, designated Y1, Y2, Y4 and Y5 receptors (Y1R, Y2R, Y4R, Y5R). Among the NPY receptors the Y4R is unique, as it prefers PP over NPY and PYY as ...

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Translation of the abstract (German)

Zur Neuropeptid Y (NPY) Familie zählen die Peptide Neuropeptid Y (NPY), Peptid YY (PYY) und das Pankreatische Polypeptid (PP), die jeweils 36 Aminosäuren besitzen. Im Menschen werden die biologischen Effekte durch vier Rezeptorsubtypen (Y1R, Y2R, Y4R, Y5R) vermittelt. Unter den NPY Rezeptoren besitzt der Y4R eine besondere Stellung, weil nur PP mit hoher Affinität an diesen Rezeptor bindet und ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:22 January 2018
Referee:Prof. Dr. A. Buschauer
Date of exam:21 April 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:-[³⁵S]GTPγS binding assay for the Y₂R and Y₄R - Luciferase gene reporter assay for the Y₂R and Y₄R - Radio- and fluorescent-labeled peptides for the Y₄R
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35611
Owner only: item control page

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