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Multistimulation Group Therapy in Alzheimer’s Disease Promotes Changes in Brain Functioning
Baglio, Francesca
, Griffanti, Ludovica
, Saibene, Francesca Lea, Ricci, Cristian, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference, make_name_string expected hash reference
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(2015)
Multistimulation Group Therapy in Alzheimer’s Disease Promotes Changes in Brain Functioning.
Neurorehabilitation and Neural Repair 29, pp. 13-24.
Date of publication of this fulltext: 11 May 2017 12:48
Article
DOI to cite this document: 10.5283/epub.35651
Abstract
Background. The growing social emergency represented by Alzheimer's disease (AD) and the lack of medical treatments able to modify the disease course have kindled the interest in nonpharmacological therapies. Objective. We introduced a novel nonpharmacological approach for people with AD (PWA) named Multidimensional Stimulation group Therapy (MST) to improve PWA condition in different disease ...
Background. The growing social emergency represented by Alzheimer's disease (AD) and the lack of medical treatments able to modify the disease course have kindled the interest in nonpharmacological therapies. Objective. We introduced a novel nonpharmacological approach for people with AD (PWA) named Multidimensional Stimulation group Therapy (MST) to improve PWA condition in different disease domains: cognition, behavior, and motor functioning. Methods. Enrolling 60 PWA in a mild to moderate stage of the disease, we evaluated the efficacy of MST with a randomized-controlled study. Neuropsychological and neurobehavioral measures and functional magnetic resonance imaging (fMRI) data were considered as outcome measures. Results. The following significant intervention-related changes were observed: reduction in Neuropsychiatric Inventory scale score, improvement in language and memory subscales of Alzheimer's Disease Assessment Scale-Cognitive subscale, and increased fMRI activations in temporal brain areas, right insular cortex, and thalamus. Conclusions. Cognitive-behavioral and fMRI results support the notion that MST has significant effects in improving PWA cognitive-behavioral status by restoring neural functioning.
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Details
| Item type | Article | ||||
| Journal or Publication Title | Neurorehabilitation and Neural Repair | ||||
| Publisher: | SAGE PUBLICATIONS INC | ||||
|---|---|---|---|---|---|
| Place of Publication: | THOUSAND OAKS | ||||
| Volume: | 29 | ||||
| Page Range: | pp. 13-24 | ||||
| Date | 2015 | ||||
| Institutions | Medicine > Institut für Epidemiologie und Präventivmedizin | ||||
| Identification Number |
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| Keywords | RANDOMIZED CONTROLLED-TRIAL; MILD COGNITIVE IMPAIRMENT; PSYCHOLOGICAL SYMPTOMS; DEMENTIA; STIMULATION; EXERCISE; EFFICACY; PEOPLE; CST; INTERVENTIONS; Alzheimer's disease; rehabilitation; occupational therapy; recreation therapy; cognitive therapy; magnetic resonance imaging; MRI; functional MRI; language | ||||
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-356510 | ||||
| Item ID | 35651 |
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