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Characterization of TSPO 18 kDa in neurosteroid synthesis and mitochondrial metabolism

Scheck, Luisa (2017) Characterization of TSPO 18 kDa in neurosteroid synthesis and mitochondrial metabolism. Dissertationsreihe der Fakultät für Chemie und Pharmazie der Universität Regensburg PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jul 2017 07:21

Abstract (English)

The translocator protein (18 kDa) (TSPO) is a highly conserved, ubiquitous protein with a high affinity in binding cholesterol. Located in the outer mitochondrial membrane (OMM), TSPO has been discussed as the key protein for the cholesterol transport and therefore as a critical factor in steroidogenesis for a long time. Since recent in vivo and in vitro studies using TSPO knock-out models have ...

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Translation of the abstract (German)

Das Translokatorprotein (18 kDa) (TSPO) ist ein hochkonserviertes, ubiquitäres Protein mit einer hohen Bindungsaffinität gegenüber Cholesterol. TSPO, was in der äußeren Mitochondrienmembran lokalisiert ist, wurde lange Zeit als Schlüsselprotein für den Cholesterintransport und somit als kritischer Faktor für die Steroidsynthese diskutiert. Doch die jüngsten in vivo- und in vitro-Studien, die vor ...

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Item type:Thesis of the University of Regensburg (PhD)
Series of the University of Regensburg:Dissertationsreihe der Fakultät für Chemie und Pharmazie der Universität Regensburg
Date:14 July 2017
Referee:Prof. Dr. Dr. Ekkehard Hean
Date of exam:22 June 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:TSPO; mitochondrial metabolism; respiration; neurosteroid synthesis; cholesterol, mitochondrial membrane potential, calcium homoeostasis
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35810
Owner only: item control page

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