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Dual regulation of APC/C activity by Rca1

Kies, Matthias (2018) Dual regulation of APC/C activity by Rca1. PhD, Universität Regensburg.

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Date of publication of this fulltext: 13 Jul 2018 04:51

Abstract (English)

The Anaphase-Promoting Complex/Cyclosome (APC/C) drives degradation of a large variety of mitotic cell cycle regulators. Therefore, tight regulation of APC/C activity plays a central role in proper cell cycle progression. Suppression of APC/C activity during G2-phase is crucial for entry into mitosis. This is achieved 1) by Cdk-dependent phosphorylation of the APC/C activator subunit Fzr, which ...

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Translation of the abstract (German)

Der Anaphase-Promoting Complex/Cyclosome (APC/C) vermittelt den Abbau einer Vielzahl an mitotischen Zellzyklus-regulatorischen Proteinen und eine strikte Regulation der APC/C Aktivität spielt eine zentrale Rolle im Zellzyklus. Für den Eintritt in die Mitose ist es wichtig, den APC/C in der G2-Phase inaktiv zu halten; dies geschieht 1) durch Cdk-abhängige Phosphorylierung der APC/C-aktivierenden ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:13 July 2018
Referee:Prof. Dr. Frank Sprenger and Prof Dr. Dr. Michael Krahn and Prof. Dr. Wolfgang Seufert
Date of exam:13 July 2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Cell Cycle Control
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Cell Cycle Control > Prof. Dr. Frank Sprenger
Keywords:cell cycle; mitotic entry; APC/C; SCF; Rca1; Dap
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36041
Owner only: item control page

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