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Targeted CNS Delivery via Nanoparticulate Drug Delivery Systems

Oswald, Mira (2017) Targeted CNS Delivery via Nanoparticulate Drug Delivery Systems. PhD, Universität Regensburg.

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Date of publication of this fulltext: 28 Aug 2017 04:56

Abstract (English)

The blood-brain barrier (BBB) is an extremely selective barrier that prevents undesired entry of xenobiotics and noxae into central nervous system (CNS). While essential for many physiological processes, this function is a major drawback in brain drug delivery. The fact that viruses are able to pass the BBB accounts for why research tries to mimic their structure to enable the targeted delivery ...

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Translation of the abstract (German)

Die Blut-Hirn-Schranke (BHS) ist eine selektive Barriere, die das unerwünschte Eindringen von Xenobiotika und Noxen in das zentrale Nervensystem (ZNS) verhindert. Während die Funktionalität der Blut-Hirn-Schranke für viele physiologische Vorgänge essenziell ist, stellt diese Barriere einen großen Nachteil im Hinblick auf die Passage von Wirkstoffen in das ZNS dar. Die Tatsache, dass Viren in der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:28 August 2017
Referee:Prof. Dr. Achim Göpferich
Date of exam:7 July 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:Rabiesvirus-Glykopeptide; ELSD; Maleimide; Blood-brain barrier; CNS; Liposomes
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36046
Owner only: item control page

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