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Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

Karlstetter, M. ; Nothdurfter, C. ; Aslanidis, A. ; Moeller, K. ; Horn, F. ; Scholz, R. ; Neumann, H. ; Weber, Bernhard H. F. ; Rupprecht, R. ; Langmann, T.



Abstract

Background: The translocator protein (18 kDa) (TSPO) is a mitochondrial protein expressed on reactive glial cells and a biomarker for gliosis in the brain. TSPO ligands have been shown to reduce neuroinflammation in several mouse models of neurodegeneration. Here, we analyzed TSPO expression in mouse and human retinal microglia and studied the effects of the TSPO ligand XBD173 on microglial ...

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