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Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

Karlstetter, M, Nothdurfter, C, Aslanidis, A, Moeller, K, Horn, F, Scholz, R, Neumann, H, Weber, Bernhard H. F. , Rupprecht, R and Langmann, T (2014) Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. Journal of Neuroinflammation 11 (3).

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Other URL: https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-11-3


Abstract

Background The translocator protein (18 kDa) (TSPO) is a mitochondrial protein expressed on reactive glial cells and a biomarker for gliosis in the brain. TSPO ligands have been shown to reduce neuroinflammation in several mouse models of neurodegeneration. Here, we analyzed TSPO expression in mouse and human retinal microglia and studied the effects of the TSPO ligand XBD173 on microglial ...

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Item type:Article
Date:2014
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1186/1742-2094-11-3DOI
24397957PubMed ID
Keywords:Translocator protein (18 kDa) Microglia Retinal degeneration Phagocytosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36078
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