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Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis

Schlossmann, Jens, Schinner, Elisabeth, Wetzl, Veronika, Schramm, Andrea, Kees, Frieder, Sandner, Peter, Stasch, Johannes-Peter and Hofmann, Franz (2017) Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis. FEBS openbio 7 (4), pp. 550-561.

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Date of publication of this fulltext: 04 Sep 2017 07:26

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Other URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377407/

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP-dependent kinase I (cGKI) are mediated via regulation of the TGFb signalling pathway, both via ERK and the Smad-dependent ...

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Item type:Article
Date:1 March 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1002/2211-5463.12202DOI
Keywords:UNILATERAL URETERAL OBSTRUCTION; PLASMINOGEN-ACTIVATOR INHIBITOR-1; GROWTH-FACTOR; MATRIX METALLOPROTEINASES; PROTEIN; STIMULATION; DAMAGE; RELIEF; HYPERTENSION; PROGRESSION; cGMP-dependent protein kinase I; cyclic guanosine monophosphate; renal fibrosis; soluble guanylate cyclase stimulation
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36134
Owner only: item control page

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