Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-361346
DOI to cite this document:: 10.5283/epub.36134

Schlossmann, Jens ; Schinner, Elisabeth ; Wetzl, Veronika ; Schramm, Andrea ; Kees, Frieder ; Sandner, Peter ; Stasch, Johannes-Peter ; Hofmann, Franz

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Date of publication of this fulltext: 04 Sep 2017 07:26

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Abstract

Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP-dependent kinase I (cGKI) are mediated via regulation of the TGFb signalling pathway, both via ERK and the Smad-dependent ...