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Inhibition of the TGFβ signalling pathway by cGMP and cGMP‐dependent kinase I in renal fibrosis

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Schlossmann, Jens ; Schinner, Elisabeth ; Wetzl, Veronika ; Schramm, Andrea ; Kees, Frieder ; Sandner, Peter ; Stasch, Johannes-Peter ; Hofmann, Franz
Date of publication of this fulltext: 04 Sep 2017 07:26


Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP-dependent kinase I (cGKI) are mediated via regulation of the TGFb signalling pathway, both via ERK and the Smad-dependent ...


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