Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-361797
DOI to cite this document:: 10.5283/epub.36179

Arndt, Stephanie ; Wacker, Eva ; Dorn, Christoph ; Koch, Andreas ; Saugspier, Michael ; Thasler, W. E. ; Hartmann, Arndt ; Bosserhoff, Anja-Katrin

; Hellerbrand, Claus

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Date of publication of this fulltext: 11 Sep 2017 06:37

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Abstract

Objective Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this study was to investigate the expression and function of BMP6 in chronic liver disease. Design BMP6 was ...