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Garcke, Harald ; Lam, Kei Fong ; Nürnberg, Robert ; Sitka, Emanuel

A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis

Garcke, Harald, Lam, Kei Fong, Nürnberg, Robert und Sitka, Emanuel (2017) A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis. Preprintreihe der Fakultät Mathematik 4/2017, Working Paper. (Eingereicht)

Veröffentlichungsdatum dieses Volltextes: 17 Okt 2017 06:06
Monographie
DOI zum Zitieren dieses Dokuments: 10.5283/epub.36244


Zusammenfassung

We derive a Cahn{Hilliard{Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a coupling of the Cahn{Hilliard{Darcy equations to a system of reaction-diffusion equations a multitude of phenomena such as nutrient diffusion and consumption, ...

We derive a Cahn{Hilliard{Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a coupling of
the Cahn{Hilliard{Darcy equations to a system of reaction-diffusion equations a multitude of phenomena such as nutrient diffusion and consumption, angiogenesis, hypoxia,
blood vessel growth, and inhibition by toxic agents, which are released for example by the necrotic cells, can be included. A new feature of the modelling approach is that a volume-averaged velocity is used, which dramatically simplifies the resulting equations. With the help of formally matched asymptotic analysis we develop new sharp interface models. Finite element numerical computations are performed and in
particular the effects of necrosis on tumour growth is investigated numerically.


Beteiligte Einrichtungen


Details

DokumentenartMonographie (Working Paper)
Schriftenreihe der Universität Regensburg:Preprintreihe der Fakultät Mathematik
Band:4/2017
Datum2017
InstitutionenMathematik > Prof. Dr. Harald Garcke
Klassifikation
NotationArt
92B05MSC
35K57MSC
35R35MSC
65M60MSC
Stichwörter / Keywordsmultiphase tumour growth, phase field model, Darcy ow, necrosis, cellular adhesion, matched asymptotic expansions, finite element computations
Dewey-Dezimal-Klassifikation500 Naturwissenschaften und Mathematik > 510 Mathematik
StatusEingereicht
BegutachtetNein, diese Version wurde noch nicht begutachtet (bei preprints)
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-362445
Dokumenten-ID36244

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