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Selective Single C(sp3)−F Bond Cleavage in Trifluoromethylarenes: Merging Visible-Light Catalysis with Lewis Acid Activation

Chen, Kang, Berg, Nele, Gschwind, Ruth Maria and König, Burkhard (2017) Selective Single C(sp3)−F Bond Cleavage in Trifluoromethylarenes: Merging Visible-Light Catalysis with Lewis Acid Activation. Journal of the American Chemical Society 139, pp. 18444-18447.

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Abstract

The conversion of easily available trifluoromethylarenes into aryldifluoromethyl compounds, which are valuable motifs in the pharmaceutical chemistry, is highly atom-and step-economical. However, the single C(sp(3))-F bond cleavage of ArCF3 is a great challenge because of the chemical inertness of the C(sp(3))-F bond and the difficult selectivity control of monodefluorination. We report here the ...

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Item type:Article
Date:November 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Chemistry and Pharmacy > Institut für Organische Chemie
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind
Projects:GRK 1626 Chemische Photokatalyse
Identification Number:
ValueType
10.1021/jacs.7b10755DOI
Keywords:C-F BOND; ELECTRON-TRANSFER REACTIONS; FACILE ACCESS; MEDICINAL CHEMISTRY; HYDRODEFLUORINATION; FLUORINE; FUNCTIONALIZATION; ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE; DERIVATIVES; ALKYLATION;
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36420
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