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Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms

Li, Y. ; Sekula, P. ; Wuttke, M. ; Wahrheit, J. ; Hausknecht, B. ; Schultheiss, U. T. ; Gronwald, Wolfram ; Schlosser, P. ; Tucci, S. ; Ekici, A. B. ; Spiekerkoetter, U. ; Kronenberg, F. ; Eckardt, K. U. ; Oefner, Peter J. ; Köttgen, Anna


Background The kidneys have a central role in the generation, turnover, transport, and excretion of metabolites, and these functions can be altered in CKD. Genetic studies of metabolite concentrations can identify proteins performing these functions. Methods We conducted genome-wide association studies and aggregate rare variant tests of the concentrations of 139 serum metabolites and 41 urine ...


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