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Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms

Li, Y., Sekula, P., Wuttke, M., Wahrheit, J., Hausknecht, B., Schultheiss, U. T., Gronwald, Wolfram, Schlosser, P., Tucci, S., Ekici, A. B., Spiekerkoetter, U., Kronenberg, F., Eckardt, K. U., Oefner, Peter J. and Kottgen, A. (2018) Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms. J. Am. Soc. Nephrol..

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Other URL: http://jasn.asnjournals.org/content/early/2018/03/14/ASN.2017101099.long


Abstract

The kidneys have a central role in the generation, turnover, transport, and excretion of metabolites, and these functions can be altered in CKD. Genetic studies of metabolite concentrations can identify proteins performing these functions.Methods We conducted genome-wide association studies and aggregate rare variant tests of the concentrations of 139 serum metabolites and 41 urine metabolites, ...

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Item type:Article
Date:15 March 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
29545352PubMed ID
10.1681/ASN.2017101099DOI
Keywords:chronic kidney disease, genome-wide association studies, metabolites, renal tubular epithelial cells
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36945
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