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Impact of Experimental Variables on the Protein Binding of Tigecycline in Human Plasma as Determined by Ultrafiltration

Dorn, Christoph , Kratzer, Alexander, Liebchen, Uwe, Schleibinger, Michael, Murschhauser, Alexandra, Schlossmann, Jens, Kees, Frieder, Simon, Philipp and Kees, Martin G. (2018) Impact of Experimental Variables on the Protein Binding of Tigecycline in Human Plasma as Determined by Ultrafiltration. Journal of Pharmaceutical Sciences 107 (2), pp. 739-744.

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Other URL: http://doi.org/10.1016/j.xphs.2017.09.006


Abstract

Tigecycline, a tetracycline derivative, shows atypical plasma protein binding behavior. The unbound fraction decreases with increasing concentration at therapeutic concentrations. Moreover, uncertainty exists about the magnitude of tigecyline's protein binding in man. Unbound fractions between 2.5% and 35% have been reported in plasma from healthy volunteers, and between 25% and 100% in patients, ...

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Item type:Article
Date:2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Group Clinical Pharmacy (Dr. Dorn)
Identification Number:
ValueType
10.1016/j.xphs.2017.09.006DOI
Keywords:HPLC (high-performance/pressure liquid chromatography), albumin, bioanalysis, antiinfectives, chelation, tetracycline, unbound fraction, patients, pH, calcium
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36970
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