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Impact of Experimental Variables on the Protein Binding of Tigecycline in Human Plasma as Determined by Ultrafiltration

Dorn, Christoph ; Kratzer, Alexander ; Liebchen, Uwe ; Schleibinger, Michael ; Murschhauser, Alexandra ; Schlossmann, Jens ; Kees, Frieder ; Simon, Philipp ; Kees, Martin G.



Abstract

Tigecycline, a tetracycline derivative, shows atypical plasma protein binding behavior. The unbound fraction decreases with increasing concentration at therapeutic concentrations. Moreover, uncertainty exists about the magnitude of tigecyline's protein binding in man. Unbound fractions between 2.5% and 35% have been reported in plasma from healthy volunteers, and between 25% and 100% in patients, ...

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