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Increased expression of c-Jun in nonalcoholic fatty liver disease

Dorn, Christoph ; Engelmann, Julia C. ; Saugspier, Michael ; Koch, Andreas ; Hartmann, Arndt ; Müller, Martina ; Spang, Rainer ; Bosserhoff, Anja ; Hellerbrand, Claus


Overnutrition is the major cause of nonalcoholic fatty liver disease (NAFLD) and its advanced form nonalcoholic steatohepatitis (NASH). We aimed to develop and characterize a murine model, which resembles both the pathology and nutritional situation, of NASH patients in Western societies. Mice were fed with a NASH-inducing diet (ND) containing sucrose, cholesterol and fats rich in saturated fatty ...


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