Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity

URN to cite this document:: urn:nbn:de:bvb:355-epub-370027
DOI to cite this document:: 10.5283/epub.37002

DeFilipp, Z. ; Peled, J. U. ; Li, S. ; Mahabamunuge, J. ; Dagher, Z. ; Slingerland, A. E. ; Del Rio, C. ; Valles, B. ; Kempner, M. E. ; Smith, M. ; Brown, J. ; Dey, B. R. ; El-Jawahri, A. ; McAfee, S. L. ; Spitzer, T. R. ; Ballen, K. K. ; Sung, A. D. ; Dalton, T. E. ; Messina, J. A. ; Dettmer, Katja ; Liebisch, G. ; Oefner, Peter J. ; Taur, Y. ; Pamer, E. G. ; Holler, E. ; Mansour, M. K. ; van den Brink, M. R. M. ; Hohmann, E. ; Jenq, R. R. ; Chen, Y. B.

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Date of publication of this fulltext: 06 Apr 2018 06:47

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Abstract

We hypothesized that third-party fecal microbiota transplantation (FMT) may restore intestinal microbiome diversity after allogeneic hematopoietic cell transplantation (allo-HCT). In this open-label single-group pilot study, 18 subjects were enrolled before allo-HCT and planned to receive third-party FMT capsules. FMT capsules were administered no later than 4 weeks after neutrophil engraftment, ...