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Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro

Saugspier, Michael ; Dorn, Christoph ; Czech, Barbara ; Gehrig, Manfred ; Heilmann, Jörg ; Hellerbrand, Claus


Bitter acids (BAs) from the hop plant Humulus lupulus L. exhibit multiple beneficial biological properties with promising effects in cancer therapy and prevention, but information regarding the effects on hepatocellular carcinoma (HCC) is missing. Here, we used two different hop bitter acid extracts enriched for either α-acids or β-acids to obtain insight into whether biological activity varies ...


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