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Therapeutisches Drug Monitoring der direkten oralen Antikoagulanzien

Böhr, Sebastian (2018) Therapeutisches Drug Monitoring der direkten oralen Antikoagulanzien. PhD, Universität Regensburg.

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Date of publication of this fulltext: 22 May 2018 11:02

Abstract (German)

Es wurde eine schnelle, robuste UHPLC-Methode zur Quantifizierung von Apixaban, Rivaroxaban, Dabigatran, sowie dessen Prodrug Dabigatranetexilat entwickelt und validiert. Es konnte die Linearität für alle Substanzen in einem Bereich von 20 – 300 ng/ml gezeigt werden. Die Nachweisgrenze und Bestimmungsgrenze lagen für Apixaban bei 4,49 und 16,47 ng/ml, für Rivaroxaban bei 4,18 und 15,39 ng/ml, für ...

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Translation of the abstract (English)

A rapid, robust UHPLC method was developed and validated to quantify apixaban, rivaroxaban, dabigatran, and its prodrug dabigatran etexilate. Linearity could be demonstrated for all substances in a range of 20 - 300 ng / ml. Detection limit and limit of quantitation were 4.49 and 16.47 ng / ml for apixaban, 4.18 and 15.39 ng / ml for rivaroxaban, 4.12 and 15.19 ng / ml for dabigatran, and ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:22 May 2018
Referee:Prof. Dr. Dr. Ekkehard Haen
Date of exam:12 April 2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Keywords:apixaban, rivaroxaban, dabigatran, TDM, therapeutisches drug monitoring, therapeutic drug monitoring, DOAK, NOAK, UHPLC, Arzneimittelinteraktionen, Konzentrationsbestimmung
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37216
Owner only: item control page

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