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Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma—a feasibility study using full slide staining

Reinke, Sarah ; Richter, Julia ; Fend, Falko ; Feller, Alfred ; Hansmann, Martin-Leo ; Hüttl, Katrin ; Oschlies, Ilske ; Ott, German ; Möller, Peter ; Rosenwald, Andreas ; Stein, Harald ; Altenbuchinger, Michael ; Spang, Rainer ; Klapper, Wolfram



Abstract

Diffuse large B-cell lymphoma (DLBCL) is subdivided by gene expression analysis (GEP) into two molecular subtypes named germinal center B-cell-like (GCB) and activated B-cell-like (ABC) after their putative cell-of-origin (COO). Determination of the COO is considered mandatory in any new-diagnosed DLBCL, not otherwise specified according to the updated WHO classification. Despite the fact that ...

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