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D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

Böttcher, Martin , Renner, Kathrin, Berger, Raffaela, Mentz, Kristin, Thomas, Simone , Cardenas-Conejo, Zugey Elizabeth, Dettmer, Katja , Oefner, Peter J. , Mackensen, Andreas, Kreutz, Marina and Mougiakakos, Dimitrios (2018) D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization. OncoImmunology 7 (7), e1445454.

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Date of publication of this fulltext: 15 May 2018 08:35

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Other URL: http://doi.org/10.1080/2162402X.2018.1445454


Abstract

D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, anoikis, and differentiation block of hematopoietic cells in an autocrine fashion. However, prognostic impact of IDH mutations and high D-2HG levels ...

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Item type:Article
Date:April 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1080/2162402X.2018.1445454DOI
29900057PubMed ID
PMC5993507PubMedCentral-ID
Keywords:immunometabolism, oncometabolite, acute myeloid leukemia, IDH mutation, Th17, Tregs, 2HG, Immunosurveillance, Inflammation and cancer
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37287
Owner only: item control page

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