D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

URN to cite this document:: urn:nbn:de:bvb:355-epub-372873

Böttcher, Martin ; Renner, Kathrin ; Berger, Raffaela

; Mentz, Kristin ; Thomas, Simone

; Cardenas-Conejo, Zugey Elizabeth ; Dettmer, Katja ; Oefner, Peter J. ; Mackensen, Andreas ; Kreutz, Marina ; Mougiakakos, Dimitrios

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Date of publication of this fulltext: 15 May 2018 08:35

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Abstract

D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, anoikis, and differentiation block of hematopoietic cells in an autocrine fashion. However, prognostic impact of IDH mutations and high D-2HG levels ...