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Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci

URN to cite this document:
urn:nbn:de:bvb:355-epub-373273
DOI to cite this document:
10.5283/epub.37327
Winkler, Thomas W. ; Brandl, Caroline ; Grassmann, Felix ; Gorski, Mathias ; Stark, Klaus ; Loss, Julika ; Weber, Bernhard H. F. ; Heid, Iris M.
Date of publication of this fulltext: 15 May 2018 10:41



Abstract

Late-stage age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly with a complex etiology.The most important non-modifiable risk factors for onset and progression of late AMD are age and genetic risk factors, however, little is known about the interplay between genetics and age or sex. Here, we conducted a large-scale age-and sex-stratified genome-wide ...

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