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Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor

Yang, Zhenlin, Han, Shuo, Keller, Max , Kaiser, Anette, Bender, Brain J., Bosse, Mathias, Burkert, Kerstin, Kögler, Lisa M., Wifling, David , Bernhardt, Günther, Plank, Nicole, Littmann, Timo, Schmidt, Peter, Yi, Cuiying, Li, Beibei, Ye, Sheng, Zhang, Rongguang, Xu, Bo, Larhammar, Dan, Stevens, Raymond C., Huster, Daniel, Meiler, Jens, Zhao, Qiang, Beck-Sickinger, Annette G., Buschauer, Armin and Wu, Beili (2018) Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor.
Nature 556, pp. 520-524.

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Abstract

Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology1,2. The NPY–Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y1, Y2, Y4 and Y5 receptors, with different ...

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Item type:Article
Date:18 April 2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1038/s41586-018-0046-xDOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37421
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