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Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor

Yang, Zhenlin ; Han, Shuo ; Keller, Max ; Kaiser, Anette ; Bender, Brain J. ; Bosse, Mathias ; Burkert, Kerstin ; Kögler, Lisa M. ; Wifling, David ; Bernhardt, Günther ; Plank, Nicole ; Littmann, Timo ; Schmidt, Peter ; Yi, Cuiying ; Li, Beibei ; Ye, Sheng ; Zhang, Rongguang ; Xu, Bo ; Larhammar, Dan ; Stevens, Raymond C. ; Huster, Daniel ; Meiler, Jens ; Zhao, Qiang ; Beck-Sickinger, Annette G. ; Buschauer, Armin ; Wu, Beili



Abstract

Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology1,2. The NPY–Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y1, Y2, Y4 and Y5 receptors, with different ...

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