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Structural basis of ligand binding modes at the
neuropeptide Y Y1 receptor

Yang, Zhenlin ; Han, Shuo ; Keller, Max ; Kaiser, Anette ; Bender, Brain J. ; Bosse, Mathias ; Burkert, Kerstin ; Kögler, Lisa M. ; Wifling, David ; Bernhardt, Günther ; Plank, Nicole ; Littmann, Timo ; Schmidt, Peter ; Yi, Cuiying ; Li, Beibei ; Ye, Sheng ; Zhang, Rongguang ; Xu, Bo ; Larhammar, Dan ; Stevens, Raymond C. ; Huster, Daniel ; Meiler, Jens ; Zhao, Qiang ; Beck-Sickinger, Annette G. ; Buschauer, Armin ; Wu, Beili


Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology(1,2). The NPY-Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y-1, Y-2, Y-4 and Y-5 receptors, with ...


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