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Optimization and Application of Non-Uniform Sampling for 2D NMR-Based Metabolomics

Freiin von Schlippenbach, Trixi Kristina (2018) Optimization and Application of Non-Uniform Sampling for 2D NMR-Based Metabolomics. PhD, Universität Regensburg.

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Date of publication of this fulltext: 31 Jul 2018 08:44

Abstract (English)

INTRODUCTION. Non-uniform sampling (NUS) accelerates the acquisition of otherwise uniformly sampled (US) multidimensional NMR spectra which offer higher resolution than 1D 1H spectra but need considerably longer measurement times. NUS in metabolomics so far has been primarily tested on pure samples or synthetic model mixtures containing predefined metabolites in non-physiological concentrations. ...

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Translation of the abstract (German)

EINLEITUNG. Non-uniform sampling (NUS) beschleunigt die Aufnahme von anderenfalls uniform gesampelten (US) multidimensionalen NMR Spektren, die eine erhöhte Auflösung gegenüber 1D 1H Spektren bieten, aber erheblich längere Messzeiten fordern. NUS in der Metabolomik wurde bisher primär an Reinsubstanzen oder synthetischen Modell-Mischungen mit vordefinierten Metaboliten in nicht-physiologischen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:31 July 2018
Referee:Prof. Dr. Wolfram Gronwald
Date of exam:30 July 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Keywords:NUS, non-uniform sampling, metabolomics, NMR, 2D
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37569
Owner only: item control page

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