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Development of photoswitchable inhibitors for β-galactosidase

Rustler, Karin ; Mickert, Matthias J. ; Nazet, Julian ; Merkl, Rainer ; Gorris, Hans H. ; König, Burkhard


Azobenzenes are of particular interest as a photochromic scaffold for biological applications because of their high fatigue resistance, their large geometrical change between extended (trans) and bent (cis) isomer, and their diverse synthetic accessibility. Despite their wide-spread use, there is no reported photochromic inhibitor of the well-investigated enzyme -galactosidase, which plays an ...


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