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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the

Zdralevic, M., Brand, A., Di Ianni, L., Dettmer, Katja , Reinders, Jörg , Singer, K., Peter, K., Schnell, A., Bruss, C., Decking, S. M., Koehl, G., Felipe-Abrio, B., Durivault, J., Bayer, P., Evangelista, M., O'Brien, T., Oefner, Peter J. , Renner, K., Pouyssegur, J. and Kreutz, Marina (2018) Double genetic disruption of lactate dehydrogenases A and B is required to ablate the. J. Biol. Chem. 293 (41), pp. 15947-15961.

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Abstract

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion. To elucidate its role in tumor growth, we disrupted both the LDHA and LDHB ...

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Item type:Article
Date:12 October 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
30158244PubMed ID
10.1074/jbc.RA118.004180DOI
Keywords:CRISPR/Cas; LDHA; LDHB; OXPHOS; Warburg effect; cancer biology; genetic disruption; glucose metabolism; glycolysis; lactate dehydrogenase; lactic acid; metabolic plasticity; pentose phosphate pathway (PPP); tumor growth; tumor metabolism
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37895
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