Startseite UR

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the

Zdralevic, M. ; Brand, A. ; Di Ianni, L. ; Dettmer, Katja ; Reinders, Jörg ; Singer, K. ; Peter, K. ; Schnell, A. ; Bruss, C. ; Decking, S. M. ; Koehl, G. ; Felipe-Abrio, B. ; Durivault, J. ; Bayer, P. ; Evangelista, M. ; O'Brien, T. ; Oefner, Peter J. ; Renner, K. ; Pouyssegur, J. ; Kreutz, Marina



Zusammenfassung

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the Warburg effect because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion. To elucidate its role in tumor growth, we disrupted both the LDHA and LDHB ...

plus


Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de
0941 943 -4239 oder -69394

Dissertationen: dissertationen@ur.de
0941 943 -3904

Forschungsdaten: datahub@ur.de
0941 943 -5707

Ansprechpartner