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Double genetic disruption of lactate dehydrogenases A and B is required to ablate the

Zdralevic, M. ; Brand, A. ; Di Ianni, L. ; Dettmer, Katja ; Reinders, Jörg ; Singer, K. ; Peter, K. ; Schnell, A. ; Bruss, C. ; Decking, S. M. ; Koehl, G. ; Felipe-Abrio, B. ; Durivault, J. ; Bayer, P. ; Evangelista, M. ; O'Brien, T. ; Oefner, Peter J. ; Renner, K. ; Pouyssegur, J. ; Kreutz, Marina



Abstract

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the Warburg effect because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion. To elucidate its role in tumor growth, we disrupted both the LDHA and LDHB ...

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