Zdralevic, M., Brand, A., Di Ianni, L., Dettmer, Katja 
, Reinders, Jörg , Singer, K., Peter, K., Schnell, A., Bruss, C., Decking, S. M., Koehl, G., Felipe-Abrio, B., Durivault, J., Bayer, P., Evangelista, M., O'Brien, T., Oefner, Peter J. , Renner, K., Pouyssegur, J. and Kreutz, Marina
(2018)
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the.
J. Biol. Chem. 293 (41), pp. 15947-15961.
Full text not available from this repository.
Other URL: http://www.jbc.org/content/293/41/15947.long
Abstract
Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion. To elucidate its role in tumor growth, we disrupted both the LDHA and LDHB ...
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| Item type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Date: | 12 October 2018 | ||||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) | ||||||
| Identification Number: |
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| Keywords: | CRISPR/Cas; LDHA; LDHB; OXPHOS; Warburg effect; cancer biology; genetic disruption; glucose metabolism; glycolysis; lactate dehydrogenase; lactic acid; metabolic plasticity; pentose phosphate pathway (PPP); tumor growth; tumor metabolism | ||||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Partially | ||||||
| Item ID: | 37895 |
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