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A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells

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Littmann, Timo ; Ozawa, Takeaki ; Hoffmann, Carsten ; Buschauer, Armin ; Bernhardt, Günther
Date of publication of this fulltext: 23 Jan 2019 17:56


The earlier an activation of a G protein-dependent signalling cascade at a G protein-coupled receptor (GPCR) is probed, the less amplificatory effects contribute to the measured signal. This is especially useful in case of a precise quantification of agonist efficacies, and is of paramount importance, when determining agonist bias in relation to the beta-arrestin pathway. As most canonical assays ...


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