Littmann, Timo, Ozawa, Takeaki, Hoffmann, Carsten, Buschauer, Armin and Bernhardt, Günther (2018) A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells. Scientific Reports 8 (17179), pp. 1-10.
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Other URL: http://doi.org/10.1038/s41598-018-35615-w
Abstract
The earlier an activation of a G protein-dependent signalling cascade at a G protein-coupled receptor (GPCR) is probed, the less amplificatory effects contribute to the measured signal. This is especially useful in case of a precise quantification of agonist efficacies, and is of paramount importance, when determining agonist bias in relation to the β-arrestin pathway. As most canonical assays ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 21 November 2018 | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 38255 |
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