| License: Creative Commons Attribution 4.0 (2MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-382558
- DOI to cite this document:
- 10.5283/epub.38255
Abstract
The earlier an activation of a G protein-dependent signalling cascade at a G protein-coupled receptor (GPCR) is probed, the less amplificatory effects contribute to the measured signal. This is especially useful in case of a precise quantification of agonist efficacies, and is of paramount importance, when determining agonist bias in relation to the beta-arrestin pathway. As most canonical assays ...

Owner only: item control page