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Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle−Receptor Interactions

Abstiens, Kathrin ; Gregoritza, Manuel ; Goepferich, Achim



Abstract

Although there are a large number of studies available for the evaluation of the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0-100% surface functionalization) were combined with different poly(ethylene glycol) (PEG) spacer lengths ...

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