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Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle−Receptor Interactions

Abstiens, Kathrin , Gregoritza, Manuel and Goepferich, Achim (2018) Ligand Density and Linker Length are Critical Factors for Multivalent Nanoparticle−Receptor Interactions. ACS Applied Materials & Interfaces 11 (1), pp. 1311-1320.

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Abstract

Although there are a large number of studies available for the evaluation of the therapeutic efficacy of targeted polymeric nanoparticles, little is known about the critical attributes that can further influence their uptake into target cells. In this study, varying cRGD ligand densities (0–100% surface functionalization) were combined with different poly(ethylene glycol) (PEG) spacer lengths ...

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Item type:Article
Date:6 December 2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1021/acsami.8b18843DOI
Keywords:integrin targeting; linker length; multivalency; polymeric nanoparticles; uptake efficiency
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38261
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