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Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing

Moschall, Rebecca, Rass, Mathias, Rossbach, Oliver, Lehmann, Gerhard, Kullmann, Lars, Eichner, Norbert, Strauss, Daniela, Meister, Gunter, Schneuwly, Stephan, Krahn, Michael P and Medenbach, Jan (2018) Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing. Nucleic Acids Research 2018 (1), pp. 1-13.

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Date of publication of this fulltext: 29 Jan 2019 10:14

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Other URL: http://doi.org/10.1093/nar/gky1284, https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky1284/5264285


Abstract

In Drosophila, female development is governed by a single RNA-binding protein, Sex-lethal (Sxl), that controls the expression of key factors involved in dosage compensation, germline homeostasis and the establishment of female morphology and behaviour. Sxl expression in female flies is maintained by an auto-regulatory, positive feedback loop with Sxl controlling splicing of its own mRNA. Until ...

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Item type:Article
Date:27 December 2018
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1093/nar/gky1284DOI
Keywords:Gene Regulation, Chromatin and Epigenetics
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38274
Owner only: item control page

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