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Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing

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Moschall, Rebecca ; Rass, Mathias ; Rossbach, Oliver ; Lehmann, Gerhard ; Kullmann, Lars ; Eichner, Norbert ; Strauss, Daniela ; Meister, Gunter ; Schneuwly, Stephan ; Krahn, Michael P. ; Medenbach, Jan
Date of publication of this fulltext: 29 Jan 2019 10:14


In Drosophila, female development is governed by a single RNA-binding protein, Sex-lethal (Sxl), that controls the expression of key factors involved in dosage compensation, germline homeostasis and the establishment of female morphology and behaviour. Sxl expression in female flies is maintained by an auto-regulatory, positive feedback loop with Sxl controlling splicing of its own mRNA. Until ...


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