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Microfluidic manufacturing improves polydispersity of multicomponent polymeric nanoparticles

Abstiens, Kathrin and Göpferich, Achim (2019) Microfluidic manufacturing improves polydispersity of multicomponent polymeric nanoparticles. Journal of Drug Delivery Science and Technology 49, pp. 433-439.

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Abstract

A key challenge in manufacturing of multicomponent polymeric colloids is obtaining monodisperse nanoparticles (NPs) with reproducible characteristics. Herein, NP formulations with varying core to shell ratios were either prepared by bulk nanoprecipitation or microfluidic synthesis and evaluated regarding their size and polydispersity. Microfluidic process parameters, such as the total flow rate ...

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Item type:Article
Date:2019
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.jddst.2018.12.009DOI
Keywords:Polymeric nanoparticles, Microfluidics, Core-shell ratio, Bulk nanoprecipitation, Block copolymers
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38281
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