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Microfluidic manufacturing improves polydispersity of multicomponent polymeric nanoparticles

Abstiens, Kathrin ; Göpferich, Achim



Abstract

A key challenge in manufacturing of multicomponent polymeric colloids is obtaining monodisperse nanoparticles (NPs) with reproducible characteristics. Herein, NP formulations with varying core to shell ratios were either prepared by bulk nanoprecipitation or microfluidic synthesis and evaluated regarding their size and polydispersity. Microfluidic process parameters, such as the total flow rate ...

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