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Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells

Schäfer, Claudia ; Göder, Anja ; Beyer, Mandy ; Kiweler, Nicole ; Mahendrarajah, Nisintha ; Rauch, Anke ; Nikolova, Teodora ; Stojanovic, Natasa ; Wieczorek, Martin ; Reich, Thomas R. ; Tomicic, Maja T. ; Linnebacher, Michael ; Sonnemann, Jürgen ; Dietrich, Sascha ; Sellmer, Andreas ; Mahboobi, Siavosh ; Heinzel, Thorsten ; Schneider, Günter ; Krämer, Oliver H.



Abstract

The transcription factors NF-kappa B and p53 as well as their crosstalk determine the fate of tumor cells upon therapeutic interventions. Replicative stress and cytolcines promote signaling cascades that lead to the co-regulation of p53 and NF-kappa B. Consequently, nuclear p53/NF-kappa B signaling complexes activate NF-kappa B-dependent survival genes. The 18 histone deacetylases (HDACs) are ...

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