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HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer

Stojanovic, N. ; Hassan, Z. ; Wirth, M. ; Wenzel, P. ; Beyer, M. ; Schäfer, C. ; Brand, P. ; Kroemer, A. ; Stauber, R. H. ; Schmid, R. M. ; Arlt, A. ; Sellmer, A. ; Mahboobi, S. ; Rad, R. ; Reichert, M. ; Saur, D. ; Krämer, O. H. ; Schneider, G.



Abstract

Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert tumour-promoting functions, qualifying them as important therapeutic targets. Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the expression of p53 ...

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